Hot Topics in Medicinal Chemistry (Track)




DNA binding potency of new ferrocenyl amides

Amin Badshah
Department of Chemistry, Quaid-i-Azam University Islamabad-45320, Pakistan

Abstract:

A series of ferrocenyl amide of general formula C₁₀H₉FeC₆H₄NHCOR [R = CH₃ (3), C₂H₅ (4), C₃H₇ (5), C(CH3)3 (6), C₉H₁₉ (7), CH₂Ph(8),  C₆H₅ (9), o-toloyl (10)] have been synthesized and characterized by using different analytical techniques: elemental analysis, FT-IR, UV- Visible and multinuclear (¹H and ¹³C) NMR spectroscopy. Based on the single crystal X-rays analysis, supramolecular structure can be attributed to compounds (9) and (10) owing to the involvement of amide group in hydrogen bonding with neighboring molecules. The capability of complex to form secondary interactions is the prerequisite for DNA binding ability. This idea is supported by the DNA binding study of these complexes by UV-Visible spectroscopy, viscometery and by laser light scattering techniques. These studies proposed that these complexes cause damage to the DNA structure via intercalation and double-helix scissoring. In addition to this, the DNA binding strength is highly dependent on the attached substituent with the amide group.